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Hear Res. 2011 Nov;281(1-2):28-37. doi: 10.1016/j.heares.2011.05.008. Epub 2011 May 27.

New developments in aminoglycoside therapy and ototoxicity.

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1
Kresge Hearing Research Institute, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5616, USA.

Abstract

After almost seven decades in clinical use, aminoglycoside antibiotics still remain indispensible drugs for acute infections and specific indications such as tuberculosis or the containment of pseudomonas bacteria in patients with cystic fibrosis. The review will describe the pathology and pathophysiology of aminoglycoside-induced auditory and vestibular toxicity in humans and experimental animals and explore contemporary views of the mechanisms of cell death. It will also outline the current state of protective therapy and recent advances in the development of aminoglycoside derivatives with low toxicity profiles for antimicrobial treatment and for stop-codon suppression in the attenuation of genetic disorders.

PMID:
21640178
PMCID:
PMC3169717
DOI:
10.1016/j.heares.2011.05.008
[Indexed for MEDLINE]
Free PMC Article
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