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J Nat Prod. 2011 Jun 24;74(6):1500-2. doi: 10.1021/np1006179. Epub 2011 Jun 3.

Identification of a naturally occurring quinazolin-4(3H)-one firefly luciferase inhibitor.

Author information

1
MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II 117528, Singapore. brinda@merlionpharma.com

Abstract

A prefractionated Streptomyces-derived extract was initially identified as being active using a luciferase-based AMP-activated protein kinase (AMPK) assay. Bioassay-guided fractionation led to the isolation of the new compound quinazolin-4(3H)-one (1) as the active component. However, 1 was shown to have potent firefly luciferase inhibitory activity with no effect on AMPK. This is the first report of a natural luciferase inhibitor.

PMID:
21639131
DOI:
10.1021/np1006179
[Indexed for MEDLINE]

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