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Mol Nutr Food Res. 2011 Oct;55(10):1499-508. doi: 10.1002/mnfr.201000605. Epub 2011 Jun 3.

Dietary-resistant starch improves maternal glycemic control in Goto-Kakizaki rat.

Author information

1
Pennington Biomedical Research Center, Baton Rouge, LA, USA. shenli750@hotmail.com

Abstract

SCOPE:

Dietary prebiotics show potential in anti-diabetes. Dietary resistant starch (RS) has a favorable impact on gut hormone profiles, including glucagon-like peptide-1 (GLP-1) consistently released, a potent anti-diabetic incretin. Also RS reduced body fat and improved glucose tolerance in rats and mice. In the current project, we hypothesize that dietary-resistant starch can improve insulin sensitivity and pancreatic β cell mass in a type 2 diabetic rat model. Altered gut fermentation and microbiota are the initial mechanisms, and enhancement in serum GLP-1 is the secondary mechanism.

METHODS AND RESULTS:

In this study, GK rats were fed an RS diet with 30% RS and an energy control diet. After 10 wk, these rats were mated and went through pregnancy and lactation. At the end of the study, pancreatic β cell mass, insulin sensitivity, pancreatic insulin content, total GLP-1 levels, cecal short-chain fatty acid concentrations and butyrate producing bacteria in cecal contents were greatly improved by RS feeding. The offspring of RS-fed dams showed improved fasting glucose levels and normal growth curves.

CONCLUSION:

Dietary RS is potentially of great therapeutic importance in the treatment of diabetes and improvement in outcomes of pregnancy complicated by diabetes.

PMID:
21638778
PMCID:
PMC4826617
DOI:
10.1002/mnfr.201000605
[Indexed for MEDLINE]
Free PMC Article

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