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Cell Tissue Res. 2012 Jan;347(1):257-65. doi: 10.1007/s00441-011-1194-6. Epub 2011 Jun 4.

Age-dependent alteration of TGF-β signalling in osteoarthritis.

Author information

1
Department of Rheumatology, Radboud University Nijmegen Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands. P.vanderkraan@reuma.umcn.nl

Abstract

Osteoarthritis (OA) is a disease of articular cartilage, with aging as the main risk factor. In OA, changes in chondrocytes lead to the autolytic destruction of cartilage. Transforming growth factor-β has recently been demonstrated to signal not only via activin receptor-like kinase 5 (ALK5)-induced Smad2/3 phosphorylation, but also via ALK1-induced Smad1/5/8 phosphorylation in articular cartilage. In aging cartilage and experimental OA, the ratio ALK1/ALK5 has been found to be increased, and the expression of ALK1 is correlated with matrix metalloproteinase-13 expression. The age-dependent shift towards Smad1/5/8 signalling might trigger the differentiation of articular chondrocytes with an autolytic phenotype.

PMID:
21638205
PMCID:
PMC3250613
DOI:
10.1007/s00441-011-1194-6
[Indexed for MEDLINE]
Free PMC Article

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