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Cell. 1990 Jun 29;61(7):1209-15.

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.

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Department of Cell Biology, Fairchild Center, Stanford University School of Medicine, California 94305.


One gene activator protein may interfere with the effects of another in eukaryotic cells. We report here that a hybrid yeast-herpes gene activator protein inhibits transcriptional activation by a thymidine-rich DNA element in yeast. This example of activator interference can be faithfully reproduced in vitro. Interference is reversed by a partially purified yeast component, but not by RNA polymerase II or various polymerase II transcription factors. We conclude that the partially purified yeast component is a novel factor, and we suggest this factor mediates the transcriptional activation process.

[Indexed for MEDLINE]

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