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Tuberculosis (Edinb). 2011 Jul;91(4):339-41. doi: 10.1016/j.tube.2011.05.003. Epub 2011 Jun 1.

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.

Author information

1
Novartis Institute for Tropical Diseases, #05-01 Chromos, 10 Biopolis road, Singapore 138670, Singapore. Yixiong_heng@immunol.a-star.edu.sg

Abstract

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

PMID:
21636324
DOI:
10.1016/j.tube.2011.05.003
[Indexed for MEDLINE]

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