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Epilepsy Res. 2011 Sep;96(1-2):185-9. doi: 10.1016/j.eplepsyres.2011.05.007. Epub 2011 Jun 1.

Effects of acetazolamide on epileptic apnea in migrating partial seizures in infancy.

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1
Department of Child Neurology, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaita, Tokyo 187-8551, Japan.

Abstract

We report two cases of migrating partial seizures in infancy complicated with intractable epileptic apnea with severe desaturation. Ictal electroencephalography revealed migrating foci of epileptiform discharges, which spread to bilateral temporal areas resulting in the onset of apnea. Magnetoencephalography detected dipole sources at bilateral perisylvian areas. Single photon emission tomography revealed a significant ictal change in perfusion at bilateral anterior temporal lobes in one patient. Addition of acetazolamide to the regimen resulted in complete disappearance of epileptic seizures.

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