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Cardiovasc Intervent Radiol. 2012 Apr;35(2):383-90. doi: 10.1007/s00270-011-0187-x. Epub 2011 Jun 2.

Angiography in the isolated perfused kidney: radiological evaluation of vascular protection in tissue ablation by nonthermal irreversible electroporation.

Author information

1
Department of Urology, University of Magdeburg, Leipziger Stra├če 44, 39120 Magdeburg, Germany. johann.wendler@med.ovgu.de

Abstract

PURPOSE:

The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE.

METHODS:

Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys.

RESULTS:

In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave.

CONCLUSION:

The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.

PMID:
21633883
DOI:
10.1007/s00270-011-0187-x
[Indexed for MEDLINE]

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