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J Biol Chem. 2011 Jul 22;286(29):25417. doi: 10.1074/jbc.R111.266700. Epub 2011 Jun 1.

Thematic minireview series on biological applications of mass spectrometry.

Author information

1
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. f.guengerich@vanderbilt.edu

Abstract

Mass spectrometry is a powerful technique with many applications in biology as well as chemistry and physics. The increases in sensitivity and resolution of the instruments, coupled with improvements in the analysis of data, have opened new dimensions in analyses of complex biological systems. Examples presented here include drug metabolism, lipid analysis, metabolomics, quantitative proteomics, direct analysis of intact proteins, and imaging of both small molecules and proteins in tissues.

PMID:
21632545
PMCID:
PMC3138286
DOI:
10.1074/jbc.R111.266700
[Indexed for MEDLINE]
Free PMC Article

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