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IEEE Trans Biomed Eng. 2011 Oct;58(10):2947-51. doi: 10.1109/TBME.2011.2158316. Epub 2011 May 31.

Multiscale modeling of calcium dynamics in ventricular myocytes with realistic transverse tubules.

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Department of Computer Science, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.


Spatial-temporal Ca(2+) dynamics due to Ca(2+) release, buffering, and reuptaking plays a central role in studying excitation-contraction (E-C) coupling in both normal and diseased cardiac myocytes. In this paper, we employ two numerical methods, namely, the meshless method and the finite element method, to model such Ca(2+) behaviors by solving a nonlinear system of reaction-diffusion partial differential equations at two scales. In particular, a subcellular model containing several realistic transverse tubules (or t-tubules) is investigated and assumed to reside at different locations relative to the cell membrane. To this end, the Ca(2+) concentration calculated from the whole-cell modeling is adopted as part of the boundary constraint in the subcellular model. The preliminary simulations show that Ca(2+) concentration changes in ventricular myocytes are mainly influenced by calcium release from t-tubules.

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