Format

Send to

Choose Destination
J Vet Emerg Crit Care (San Antonio). 2011 Jun;21(3):268-72. doi: 10.1111/j.1476-4431.2011.00638.x. Epub 2011 Apr 29.

4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats.

Author information

1
Section of Emergency and Critical Care, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, C339 Veterinary Medical Center, University of Minnesota, St Paul, MN 55108-6192, USA. johns172@umn.edu

Abstract

OBJECTIVE:

To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity.

CASE OR SERIES SUMMARY:

All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the dose of 4-MP used, available clinicopathological data, and clinical progression during hospitalization. All patients survived to discharge.

NEW OR UNIQUE INFORMATION PROVIDED:

IV use of 4-MP at 125 mg/kg as an initial dose and 31.25 mg/kg at 12, 24, and 36 hours is safe and effective for treatment of naturally occurring EG toxicity in cats. Increased HCO₃ concentrations were noted after IV use of 4-MP. This is the first report documenting the successful treatment of naturally occurring EG intoxication in cats with 4-MP.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center