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CNS Neurol Disord Drug Targets. 2011 Aug;10(5):571-5.

Targeting interleukin-1β for pain.

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Kareus Therapeutics, Norcross, GA 30071, USA.


Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1β-receptor interactions.

[Indexed for MEDLINE]

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