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Small. 2011 Aug 22;7(16):2301-6. doi: 10.1002/smll.201100628. Epub 2011 Jun 1.

Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?

Author information

1
Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA, Fax: (+1) 216-368-3006.

Abstract

EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.

KEYWORDS:

brain tumors; gold nanoparticles; nanomedicine; photodynamic therapy; targeted delivery

PMID:
21630446
PMCID:
PMC3837553
DOI:
10.1002/smll.201100628
[Indexed for MEDLINE]
Free PMC Article

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