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J Mass Spectrom. 2011 Jun;46(6):568-71. doi: 10.1002/jms.1926.

High spatial resolution imaging mass spectrometry and classical histology on a single tissue section.

Author information

1
Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.

Abstract

The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 µm for sagittal sections of the cerebellum from rat brain.

PMID:
21630385
PMCID:
PMC3118566
DOI:
10.1002/jms.1926
[Indexed for MEDLINE]
Free PMC Article

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