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Results Probl Cell Differ. 2011;53:309-41. doi: 10.1007/978-3-642-19065-0_14.

Protein kinases and protein phosphatases that regulate meiotic maturation in mouse oocytes.

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Department of Biology, University of Pennsylvania, 433 S. University Avenue, Philadelphia, PA 19104, USA.


Oocytes arrest at prophase of meiosis I (MI) and in vivo do not resume meiosis until they receive ovulatory cues. Meiotic resumption entails two rounds of chromosome segregation without an intervening round of DNA replication and an arrest at metaphase of meiosis II (MII); fertilization triggers exit from MII and entry into interphase. During meiotic resumption, there is a burst of protein phosphorylation and dephosphorylation that dramatically changes during the course of oocyte meiotic maturation. Many of these phosphorylation and dephosphorylation events are key to regulating meiotic cell cycle arrest and/or progression, chromosome dynamics, and meiotic spindle assembly and disassembly. This review, which is subdivided into sections based upon meiotic cell cycle stages, focuses on the major protein kinases and phosphatases that have defined requirements during meiosis in mouse oocytes and, when possible, connects these regulatory pathways.

[Indexed for MEDLINE]

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