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J Infect Dis. 2011 Jul 1;204(1):60-4. doi: 10.1093/infdis/jir220.

Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19.

Author information

1
Department of Medicine, Johns Hopkins University, Johns Hopkins Bayview Medical Center, MD, USA.

Abstract

Human challenges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important enteropathogen. We report findings from the first challenge studies using ETEC-expressing colonization factor fimbria CS17 and CS19. LSN03-016011/A (LT, CS17) elicited a dose-dependent effect, with the upper dose (6 × 10(9) organisms) causing diarrhea in 88% of recipients. WS0115A (LTSTp, CS19) also showed a dose response, with a 44% diarrhea rate at 9 × 10(9) organisms. Both strains elicited homologous antifimbrial and anti-LT antibody seroconversion. These studies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials.

PMID:
21628659
PMCID:
PMC3105037
DOI:
10.1093/infdis/jir220
[Indexed for MEDLINE]
Free PMC Article

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