Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neural Transm (Vienna). 2012 Jan;119(1):53-7. doi: 10.1007/s00702-011-0664-z. Epub 2011 May 31.

Substantia nigra echogenicity in Parkinson's disease: relation to serum iron and C-reactive protein.

Author information

1
Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany. uwe.walter@med.uni-rostock.de

Abstract

In Parkinson's disease (PD), substantia nigra hyperechogenicity (SN-h) has been related to both, local iron accumulation and microglia activation. We analysed its relationship in PD patients with serum iron (n = 31) and C-reactive protein (CRP; n = 193). SN-h correlated with lower CRP and iron levels. Also, patients with a first-degree relative with PD had lower iron levels. Microglia activation, if reflected by SN-h, may be therefore unrelated to serum CRP. Findings support the idea that SN-h indicates inherited alteration of iron metabolism.

PMID:
21626410
DOI:
10.1007/s00702-011-0664-z
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center