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Mol Immunol. 2011 Aug;48(14):1643-55. doi: 10.1016/j.molimm.2011.05.001. Epub 2011 May 31.

Complement deficiency states and associated infections.

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1
Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden.

Abstract

A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed.

PMID:
21624663
DOI:
10.1016/j.molimm.2011.05.001
[Indexed for MEDLINE]
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