[Interferon alpha 2β, partial keratectomy and amniotic membrane transplant for the treatment of a recurrent conjunctival squamous carcinoma]

Arch Soc Esp Oftalmol. 2011 May;86(5):154-7. doi: 10.1016/j.oftal.2011.01.010. Epub 2011 Apr 15.
[Article in Spanish]

Abstract

Case report: An 80-year-old woman diagnosed with a recurrent squamous conjuctival carcinoma treated with surgical excision of the lesion, zonal reconstruction and topical Interferon alpha 2-β.

Discussion: Squamous conjunctival carcinoma is the most frequent neoplasm of the ocular surface. Surgical removal of the lesion is the traditional treatment, but this technique has a high recurrence rate. Interferons are glycoproteins that trigger intracellular pathways with antiviral and antitumoral properties. Recent studies have proven their activity against conjunctival carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Amnion / transplantation*
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / surgery*
  • Combined Modality Therapy
  • Conjunctiva*
  • Cornea / surgery*
  • Eye Neoplasms / drug therapy*
  • Eye Neoplasms / surgery*
  • Female
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use*
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / surgery*
  • Ophthalmologic Surgical Procedures
  • Recombinant Proteins

Substances

  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins