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Pharmacol Res. 2011 Aug;64(2):105-12. doi: 10.1016/j.phrs.2011.05.007. Epub 2011 May 20.

Pharmacokinetic and chemoprevention studies on tea in humans.

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  • 1Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, United States.


Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolites identified in humans include glucuronide/sulfate conjugates, methylated tea catechin conjugates, and microflora-mediated ring fission products and phenolic acid catabolites. Plasma levels of unchanged tea catechins in humans are mostly in the sub-μM or nM concentration range, which is much lower than the effective concentrations determined in most in vitro studies. However, some of the catechin metabolites/catabolites are present in the systemic circulation at levels much higher than those of the parent catechins. The contribution of catechin derived metabolites/catabolites to the biological effects associated with green tea is yet to be defined. A limited number of chemoprevention trials of green tea or green tea catechins have been conducted to date and have observed potential preventive activity for oral, prostate, and colorectal cancer. Emerging data from multiple ongoing intervention trials will further contribute to defining the cancer preventive activity of green tea or green tea catechins.

TRIAL REGISTRATION: NCT00949923 NCT01105338 NCT00573885 NCT01060345 NCT00363805 NCT00459407 NCT01116336 NCT00303823 NCT00516243 NCT00611650 NCT00253643 NCT00676793 NCT00917735 NCT00685516.

[PubMed - indexed for MEDLINE]
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