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J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):842-54. doi: 10.1093/gerona/glr089. Epub 2011 May 28.

Genetic dissection of late-life fertility in Caenorhabditis elegans.

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1
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA. alexander.mendenhall@colorado.edu

Abstract

The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility when mated after the self-fertile period but did not report the functional limits. Here, we report the functional life span of the C elegans germ line when mating with males. We show that C elegans can regain fertility late in life (significantly later than in previous reports) and that the end of this period corresponds quite well to its 3-week total life span. Genetic analysis reveals that late-life fertility is controlled by conserved pathways involved with aging and dietary restriction.

PMID:
21622982
PMCID:
PMC3148761
DOI:
10.1093/gerona/glr089
[Indexed for MEDLINE]
Free PMC Article
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