Format

Send to

Choose Destination
See comment in PubMed Commons below
J Bacteriol. 2011 Aug;193(15):3956-63. doi: 10.1128/JB.00277-11. Epub 2011 May 27.

Comparative genomic analysis of the hexuronate metabolism genes and their regulation in gammaproteobacteria.

Author information

1
State Research Institute of Genetics and Selection of Industrial Microorganisms (GosNIIGenetika), Moscow, Russia.

Abstract

The hexuronate metabolism in Escherichia coli is regulated by two related transcription factors from the FadR subfamily of the GntR family, UxuR and ExuR. UxuR controls the d-glucuronate metabolism, while ExuR represses genes involved in the metabolism of all hexuronates. We use a comparative genomics approach to reconstruct the hexuronate metabolic pathways and transcriptional regulons in gammaproteobacteria. We demonstrate differences in the binding motifs of UxuR and ExuR, identify new candidate members of the UxuR/ExuR regulons, and describe the links between the UxuR/ExuR regulons and the adjacent regulons UidR, KdgR, and YjjM. We provide experimental evidence that two predicted members of the UxuR regulon, yjjM and yjjN, are the subject of complex regulation by this transcription factor in E. coli.

PMID:
21622752
PMCID:
PMC3147527
DOI:
10.1128/JB.00277-11
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center