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Neurobiol Aging. 2011 Oct;32(10):1924.e1-3. doi: 10.1016/j.neurobiolaging.2011.03.023. Epub 2011 May 28.

No association of toll-like receptor 2 polymorphisms with Alzheimer's disease in Han Chinese.

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1
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. yu-jintai@163.com

Abstract

Toll-like receptor 2 (TLR2) represents a reasonable functional and positional candidate gene for Alzheimer's disease (AD) as it is located under the linkage region of AD on chromosome 4q, and is functionally involved in the microglia-mediated inflammatory response and amyloid β (Aβ) clearance. In the current study, 7 single nucleotide polymorphisms (SNPs) that span the TLR2 were selected and their associations with late-onset AD (LOAD) risk were assessed in a case-control sample comprising 785 individuals in a Han Chinese population. No significant differences in the frequency of TLR2 alleles, genotypes, and haplotypes in the AD cases were detected compared with the controls. TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population.

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