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Fertil Steril. 2011 Jun 30;95(8):2612-4.e1. doi: 10.1016/j.fertnstert.2011.05.003. Epub 2011 May 31.

Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice--no evidence of malignant cell contamination.

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  • 1Department of Obstetrics and Gynecology, Erlangen University Hospital, Erlangen, Germany.


This study examined the possible presence of malignant cells in ovarian cortex from patients with ovarian tumors after xenografting of the ovarian tissue into severe combined immunodeficiency mice. None of the mice presented symptoms of reintroduced malignancy nor did microscopic and immunohistochemical evaluation of the grafts raise any suspicion of residual malignant disease.

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