Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Cell Res. 2011 Jul 15;317(12):1726-35. doi: 10.1016/j.yexcr.2011.05.007. Epub 2011 May 18.

TIEG1-null tenocytes display age-dependent differences in their gene expression, adhesion, spreading and proliferation properties.

Author information

  • 1Laboratoire de Biomécanique et Bioingénierie UMR CNRS 6600, Université de Technologie de Compiègne, Compiègne, France.

Abstract

The remodeling of extracellular matrix is a crucial mechanism in tendon development and the proliferation of fibroblasts is a key factor in this process. The purpose of this study was to further elucidate the role of TIEG1 in mediating important tenocyte properties throughout the aging process. Wildtype and TIEG1 knockout tenocytes adhesion, spreading and proliferation were characterized on different substrates (fibronectin, collagen type I, gelatin and laminin) and the expression levels of various genes known to be involved with tendon development were analyzed by RT-PCR. The experiments revealed age-dependent and substrate-dependent properties for both wildtype and TIEG1 knockout tenocytes. Taken together, our results indicate an important role for TIEG1 in regulating tenocytes adhesion, spreading, and proliferation throughout the aging process. Understanding the basic mechanisms of TIEG1 in tenocytes may provide valuable information for treating multiple tendon disorders.

PMID:
21620830
PMCID:
PMC3215103
DOI:
10.1016/j.yexcr.2011.05.007
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center