Format

Send to

Choose Destination
Matrix Biol. 2011 Jun;30(5-6):356-60. doi: 10.1016/j.matbio.2011.03.010. Epub 2011 May 26.

Molecular simulations predict novel collagen conformations during cross-link loading.

Author information

1
Physiology, Biophysics & Systems Biology Program, Weill Graduate School of Medical Sciences, Cornell University, 1300 York Avenue, New York, NY 10065, USA. BourneJ@HSS.EDU

Abstract

Collagen cross-linking mechanically strengthens tissues during development and aging, but there is limited data describing how force transmitted across cross-links affects molecular conformation. We used Steered Molecular Dynamics (SMD) to model perpendicular force through a side chain. Results predicted that collagen peptides have negligible bending resistance and that mechanical force causes helix disruption below covalent bond failure strength, suggesting alternative molecular conformations precede cross-link rupture and macroscopic damage during mechanical loading.

PMID:
21620686
PMCID:
PMC3148790
DOI:
10.1016/j.matbio.2011.03.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center