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Nat Rev Immunol. 2011 May 27;11(7):489-95. doi: 10.1038/nri2993.

The golden anniversary of the thymus.

Author information

1
Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. miller@wehi.edu.au

Erratum in

  • Nat Rev Immunol. 2011 Dec;11(12):880.

Abstract

The immunological function of the thymus was first documented 50 years ago by using neonatally thymectomized mice, while studying its role in virus-induced leukaemia. Since then, an enormous wealth of reports has helped to define the importance of this primary lymphoid organ. In this article, I summarize the key advances that have led to our current knowledge of the functions of the thymus and its T cells in immunity.

PMID:
21617694
DOI:
10.1038/nri2993
[Indexed for MEDLINE]

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