Send to

Choose Destination
See comment in PubMed Commons below
Epigenetics. 2011 Jul;6(7):857-61. Epub 2011 Jul 1.

Sex differences in epigenetic mechanisms may underlie risk and resilience for mental health disorders.

Author information

  • 1Department of Psychology, University of Wisconsin, Madison, Madison, WI, USA.


Alterations in the epigenetic programming of sex differences in the brain may underlie sexually dimorphic neurodevelopmental disorders. Sex differences have been found in DNA methyltransferases 3a, DNA methylation patterns, MeCP2, and nuclear corepressor within the developing brain. Natural variations in these epigenetic mechanisms have profound consequences on gene expression and brain function. Exogenous or endogenous perturbations during development may impact these epigenetic processes and alter the trajectory of the developing brain and confer sexually dimorphic risk and resilience for developing a neurological or mental health disorder.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk