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Cancer Lett. 2011 Sep 28;308(2):152-61. doi: 10.1016/j.canlet.2011.04.023. Epub 2011 May 26.

Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.

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1
Department of Surgery, Graduate School of Medicine, Kyoto University, Japan.

Erratum in

  • Cancer Lett. 2012 Oct 28;323(2):232.

Abstract

We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance.

PMID:
21616586
DOI:
10.1016/j.canlet.2011.04.023
[Indexed for MEDLINE]
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