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Immunity. 2011 May 27;34(5):651-64. doi: 10.1016/j.immuni.2011.05.001.

Myeloid C-type lectin receptors in pathogen recognition and host defense.

Author information

1
Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, UK.

Abstract

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins. Many of them are expressed in myeloid cells and signal in response to pathogen-derived or self ligands to initiate or regulate cell activation. Here, we review the properties of myeloid CLRs, highlighting how their signaling function is coordinated with that of other innate receptor families to control immunity to infection.

PMID:
21616435
DOI:
10.1016/j.immuni.2011.05.001
[Indexed for MEDLINE]
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