Send to

Choose Destination
Immunity. 2011 May 27;34(5):637-50. doi: 10.1016/j.immuni.2011.05.006.

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

Author information

Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.


Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that play a central role in host cell recognition and responses to microbial pathogens. TLR-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted; however, the recent discovery of non-TLR PRRs, such as C-type lectin receptors, NOD-like receptors, and RIG-I-like receptors, suggests that many aspects of innate immunity are more sophisticated and complex. In this review, we will focus on the role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center