Format

Send to

Choose Destination
Immunity. 2011 May 27;34(5):629-36. doi: 10.1016/j.immuni.2011.05.009.

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Innate host defense pathways consist of microbial sensors, their signaling pathways, and the antimicrobial effector mechanisms. Several classes of host defense pathways are currently known, each comprising several pattern-recognition receptors that detect different types of pathogens. These pathways interact with one another in a variety of ways that can be categorized into cooperation, complementation, and compensation. Understanding the principles of these interactions is important for better understanding of host defense mechanisms, as well as for correct interpretation of immunodeficient phenotypes.

PMID:
21616433
PMCID:
PMC3143490
DOI:
10.1016/j.immuni.2011.05.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center