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FEBS Lett. 2011 Jun 23;585(12):1979-84. doi: 10.1016/j.febslet.2011.05.035. Epub 2011 May 20.

Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.

Author information

1
Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. huajin.wnag@yale.edu

Abstract

Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expression of lipin-1γ altered LD morphology without affecting the triacylglycerol (TG) level. In human tissues, lipin-1γ is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism.

PMID:
21616074
PMCID:
PMC3117272
DOI:
10.1016/j.febslet.2011.05.035
[Indexed for MEDLINE]
Free PMC Article

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