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Science. 1990 Jun 8;248(4960):1230-4.

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

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  • 1Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

Erratum in

  • Science 1990 Oct 26;250(4980):494.


Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

[PubMed - indexed for MEDLINE]
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