Format

Send to

Choose Destination
See comment in PubMed Commons below
Laryngorhinootologie. 2011 Jun;90(6):358-63. doi: 10.1055/s-0031-1271758. Epub 2011 May 25.

[Lymphatic and vascular invasion in laryngeal and pyriform sinus carcinomas].

[Article in German]

Author information

  • 1UMF Iuliu Hatieganu, ENT, Cluj-Napoca, Romania. chirila_magda@yahoo.com

Abstract

BACKGROUND:

To investigate prognostic significance of the lymphatic and vascular invasion in patients with squamous cell carcinoma of the larynx and pyriform sinus.

MATERIAL AND METHODS:

Patients with squamous cell carcinoma of the larynx and pyriform sinus who underwent laryngectomies between 2002 and 2006 in the ENT Clinic of Cluj-Napoca were investigated for lymphatic and vascular invasion and their effect on disease-free survival and recurrence rates.

RESULTS:

The present study included 396 patients. The mean disease-free survival of patients with or without lymphatic invasion was statistically significant (p=0.000000). The mean disease-free survival of patients with or without vascular invasion was statistically significant (p=0.000021). In multivariant analysis, the lymphatic invasion was significantly correlated only with surgical resection borders (p=0.0004), while vascular invasion was significantly correlated with surgical resection borders (p=0.0000), nodes diameter (p=0.0075) and postoperative radiotherapy and/or chemotherapy (p=0.0002).

CONCLUSION:

Lymphatic and vascular invasion have a significant prognostic value and influence the disease-free survival, regional and distant metastasis rates significantly.

PMID:
21614737
DOI:
10.1055/s-0031-1271758
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Georg Thieme Verlag Stuttgart, New York
    Loading ...
    Support Center