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Biomed Imaging Interv J. 2006 Jul;2(3):e23. doi: 10.2349/biij.2.3.e23. Epub 2006 Jul 1.

Radioimmunotherapy: a brief overview.

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1
Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Abstract

With the advent of biotechnological advances and knowledge of molecular and cellular biology, radioimmunotherapy (RIT) has become a highly promising oncologic therapeutic modality with established clinically efficacy, particularly in non-Hodgkin's lymphomas. This paper provides a short survey of the basic science of RIT and the various monoclonal antibodies and radionuclides used. A brief review of the published literature on the clinical applications of radioimmunotherapy, particularly in non-Hodgkin's lymphoma, is provided. New research data indicate many potential areas of development of this modality, including haematological and solid-organ radioimmunotherapy as well as new radionuclidic approaches and clinical protocols.

KEYWORDS:

Monoclonal antibodies; ibritumomab tiuxetan; oncology; tositumomab

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