Format

Send to

Choose Destination
Int J Mol Sci. 2010;11(12):4796-813. doi: 10.3390/ijms11124796. Epub 2010 Nov 24.

Functional toxicogenomics: mechanism-centered toxicology.

Author information

1
Department of Nutritional Science and Toxicology, University of California Berkeley, Berkeley, California 94720, USA; E-Mail: mnorth@berkeley.edu.

Abstract

Traditional toxicity testing using animal models is slow, low capacity, expensive and assesses a limited number of endpoints. Such approaches are inadequate to deal with the increasingly large number of compounds found in the environment for which there are no toxicity data. Mechanism-centered high-throughput testing represents an alternative approach to meet this pressing need but is limited by our current understanding of toxicity pathways. Functional toxicogenomics, the global study of the biological function of genes on the modulation of the toxic effect of a compound, can play an important role in identifying the essential cellular components and pathways involved in toxicity response. The combination of the identification of fundamental toxicity pathways and mechanism-centered targeted assays represents an integrated approach to advance molecular toxicology to meet the challenges of toxicity testing in the 21(st) century.

KEYWORDS:

barcoding; functional toxicogenomics; toxicity pathways; toxicity testing; yeast

PMID:
21614174
PMCID:
PMC3100848
DOI:
10.3390/ijms11124796
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center