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Schizophr Bull. 2013 Jan;39(1):52-8. doi: 10.1093/schbul/sbr049. Epub 2011 May 25.

Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia.

Author information

1
Child Psychiatry Branch, National Institutes of Mental Health, 10/3N202, 10 Center Drive, Bethesda, MD, USA. brian.weisinger@nih.gov

Abstract

BACKGROUND:

Progressive cortical gray matter (GM) abnormalities are an established feature of schizophrenia and are more pronounced in rare, severe, and treatment refractory childhood-onset schizophrenia (COS) cases. The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results.

METHODS:

Using the largest to date longitudinal sample of COS cases (n = 104, scans = 249, Male/Female [M/F] = 57/47), we compared COS sex differences with sex differences in a sample of matched typically developing children (n = 104, scans = 244, M/F = 57/47), to determine whether or not sex had differential effects on cortical and subcortical brain development in COS.

RESULTS:

Our results showed no significant differential sex effects in COS for either GM cortical thickness or subcortical volume development (sex × diagnosis × age interaction; false discovery rate q = 0.05).

CONCLUSION:

Sex appears to play a similar role in cortical and subcortical GM development in COS as it does in normally developing children.

PMID:
21613381
PMCID:
PMC3523910
DOI:
10.1093/schbul/sbr049
[Indexed for MEDLINE]
Free PMC Article
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