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Invest Ophthalmol Vis Sci. 2011 Jul 25;52(8):5525-8. doi: 10.1167/iovs.10-6827.

Evaluation of serum lipid concentrations and genetic variants at high-density lipoprotein metabolism loci and TIMP3 in age-related macular degeneration.

Author information

1
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany.

Erratum in

  • Erratum. [Invest Ophthalmol Vis Sci. 2016]

Abstract

PURPOSE:

To analyze the association between polymorphisms in the TIMP3 gene and genes of the high-density lipoprotein (HDL) metabolism and age-related macular degeneration (AMD), and evaluate serum lipid and lipoprotein levels in AMD patients compared with control individuals.

METHODS:

Single nucleotide polymorphisms in or near the TIMP3, ABCA1, FADS1-3, CETP, LIPC, and LPL genes were genotyped. Serum levels of apolipoprotein B (ApoB), apolipoprotein A1, lipoprotein a, cholesterol, triglycerides, and HDL-cholesterol were determined.

RESULTS:

Significant associations were found between AMD and variants in ABCA1 and FADS1-3, and a nearly significant association in TIMP3. No significant associations were observed for variants in LPL, LIPC, and CETP. We also observed a significant elevation of ApoB levels in serum of AMD patients. Other lipids and lipoproteins were not significantly altered.

CONCLUSIONS:

These results confirm associations of AMD with variants near the TIMP3 gene and at loci involved in HDL metabolism. They further highlight a role of the extracellular matrix and the HDL metabolism in the pathogenesis of AMD. This study identified increased ApoB levels as a possible new serum biomarker for AMD.

PMID:
21613373
DOI:
10.1167/iovs.10-6827
[Indexed for MEDLINE]

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