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Biomed Imaging Interv J. 2008 Jul;4(3):e47. doi: 10.2349/biij.4.3.e47. Epub 2008 Jul 1.

Found in translation: Integrating laboratory and clinical oncology research.

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1
Division of Radiation Oncology, Penn State Hershey Cancer Institute, Hershey, Pennsylvania, United States.

Abstract

Translational research in medicine aims to inform the clinic and the laboratory with the results of each other's work, and to bring promising and validated new therapies into clinical application. While laudable in intent, this is complicated in practice and the current state of translational research in cancer shows both striking success stories and examples of the numerous potential obstacles as well as opportunities for delays and errors in translation. This paper reviews the premises, promises, and problems of translational research with a focus on radiation oncology and suggests opportunities for improvements in future research design.

KEYWORDS:

clinical trials; protons; radiation therapy; targeted therapy; translational research

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