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Eur J Hum Genet. 2011 Oct;19(10):1095-9. doi: 10.1038/ejhg.2011.91. Epub 2011 May 25.

GWAS Integrator: a bioinformatics tool to explore human genetic associations reported in published genome-wide association studies.

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1
Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. wby0@cdc.gov

Abstract

Genome-wide association studies (GWAS) have successfully identified numerous genetic loci that are associated with phenotypic traits and diseases. GWAS Integrator is a bioinformatics tool that integrates information on these associations from the National Human Genome Research institute (NHGRI) Catalog, SNAP (SNP Annotation and Proxy Search), and the Human Genome Epidemiology (HuGE) Navigator literature database. This tool includes robust search and data mining functionalities that can be used to quickly identify relevant associations from GWAS, as well as proxy single-nucleotide polymorphisms (SNPs) and potential candidate genes. Query-based University of California Santa Cruz (UCSC) Genome Browser custom tracks are generated dynamically on the basis of users' selected GWAS hits or candidate genes from HuGE Navigator literature database (http://www.hugenavigator.net/HuGENavigator/gWAHitStartPage.do). The GWAS Integrator may help enhance inference on potential genetic associations identified from GWAS studies.

PMID:
21610748
PMCID:
PMC3190251
DOI:
10.1038/ejhg.2011.91
[Indexed for MEDLINE]
Free PMC Article
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