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J Infect Dis. 1990 Jun;161(6):1085-7.

Enhancement of human herpesvirus 6 replication in adult human lymphocytes by monoclonal antibody to CD3.

Author information

1
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.

Abstract

The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection of CBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults.

PMID:
2161036
DOI:
10.1093/infdis/161.6.1085
[Indexed for MEDLINE]

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