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Neuron. 2011 May 26;70(4):582-8. doi: 10.1016/j.neuron.2011.05.012.

Pattern separation: a common function for new neurons in hippocampus and olfactory bulb.

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  • 1Departments of Neuroscience and Psychiatry, Columbia University, New York, USA.

Abstract

While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, "Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation," in this issue of Neuron.

PMID:
21609817
PMCID:
PMC3109085
DOI:
10.1016/j.neuron.2011.05.012
[PubMed - indexed for MEDLINE]
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