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Fish Shellfish Immunol. 2011 Aug;31(2):224-31. doi: 10.1016/j.fsi.2011.05.006. Epub 2011 May 18.

Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua) revealing immune competent molecules.

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Aquatic Animal Health Research Group, Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway.


The skin mucosal proteome of Atlantic cod (Gadus morhua) was mapped using a 2D PAGE, LC-MS/MS coupled approach. Mucosal proteins from naive fish were identified primarily by similarity searches across various cod EST databases. The identified proteins were clustered into 8 groups based on gene ontology classification for biological process. Most of the proteins identified from the gel are hitherto unreported for cod. Galectin-1, mannan binding lectin (MBL), serpins, cystatin B, cyclophilin A, FK-506 binding protein, proteasome subunits (alpha-3 and -7), ubiquitin, and g-type lysozyme are considered immune competent molecules. Five of the aforementioned proteins were cloned and their tissue distribution was analysed by RT-PCR.

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