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Exp Hematol. 2011 Aug;39(8):809-16. doi: 10.1016/j.exphem.2011.04.008. Epub 2011 May 10.

Bidirectional interactions between bone metabolism and hematopoiesis.

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Centre de Recherche de l'Hôpital Sainte-Justine, Département de Pharmacologie, Université de Montréal, Canada.


Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.

[Indexed for MEDLINE]

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