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HPB (Oxford). 2011 Jun;13(6):391-9. doi: 10.1111/j.1477-2574.2011.00300.x.

Biliary complications following orthotopic liver transplantation: a 10-year audit.

Author information

1
National Hospital of Sri Lanka and New Zealand Liver Transplant Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka, nalakagunawansa@yahoo.co.uk

Abstract

BACKGROUND:

Biliary complications following liver transplantation result in major morbidity. We undertook a 10-year audit of the incidence, management and outcomes of post-transplant biliary complications at the New Zealand Liver Transplant Unit.

METHODS:

Prospectively collected data on 348 consecutive liver transplants performed between February 1998 and October 2008 were reviewed. The minimum follow-up was 6 months.

RESULTS:

A total of 309 adult and 39 paediatric transplants were performed over the study period. Of these, 296 (85%) were whole liver grafts and 52 (15%) were partial liver grafts (24 split-liver, eight reduced-size and 20 live-donor grafts). There were 80 biliary complications, which included 63 (18%) strictures and 17 (5%) bile leaks. Partial graft, a paediatric recipient and a Roux-en-Y biliary anastomosis were independent predictors of biliary strictures. Twenty-five (40%) strictures were successfully managed non-operatively and 38 (60%) required surgery (31 biliary reconstructions, three segmental resections and four retransplants). Seven (41%) bile leaks required surgical revision and 10 (59%) were managed non-operatively. There was no mortality related directly to biliary complications.

CONCLUSIONS:

Biliary complications affected one in five transplant recipients. Paediatric status, partial graft and Roux-en-Y anastomosis were independently associated with the occurrence of biliary strictures. Over half of the affected patients required surgical revision, but no mortality resulted from biliary complications.

PMID:
21609371
PMCID:
PMC3103095
DOI:
10.1111/j.1477-2574.2011.00300.x
[Indexed for MEDLINE]
Free PMC Article
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