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Muscle Nerve. 2011 Jun;43(6):897-9. doi: 10.1002/mus.22037.

Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate.

Author information

1
Cleveland FES Center, Hamman 601, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. dma18@case.edu

Abstract

Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

PMID:
21607972
PMCID:
PMC3101373
DOI:
10.1002/mus.22037
[Indexed for MEDLINE]
Free PMC Article

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