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J Neural Transm (Vienna). 2011 Jul;118(7):997-1001. doi: 10.1007/s00702-011-0655-0. Epub 2011 May 24.

Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells.

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1
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089-9121, USA.

Abstract

Monoamine oxidase (MAO) A is the major metabolizing enzyme of serotonin (5-hydroxytryptamine, 5-HT) which regulates early brain development. In this study, wild-type (WT) and MAO A(neo) embryonic stem (ES) cell lines were established from the inner cell mass of murine blastocysts and their characteristics during ES and differentiating stages were studied. Our results show that the differentiation to neural cells in MAO A(neo) ES cells was reduced compared to WT, suggesting MAO A played a regulatory role in stem cells neural differentiation.

PMID:
21607742
PMCID:
PMC3435112
DOI:
10.1007/s00702-011-0655-0
[Indexed for MEDLINE]
Free PMC Article
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