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J Clin Invest. 2011 Jun;121(6):2155-7. doi: 10.1172/JCI58329. Epub 2011 May 23.

Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?

Author information

1
Center for Immunobiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. dwilkes@iupui.edu

Abstract

Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and colleagues report that tissue hypoxia resulting in dysfunctional airway microvasculature precedes the airway fibrosis characteristic of OB. In addition, a relative deficiency of allograft endothelial cell-derived HIF-1α contributes to this process. Data showing that overexpressing HIF-1α restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis.

PMID:
21606603
PMCID:
PMC3104786
DOI:
10.1172/JCI58329
[Indexed for MEDLINE]
Free PMC Article
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