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J Clin Invest. 2011 Jun;121(6):2142-5. doi: 10.1172/JCI57935. Epub 2011 May 23.

The targeted podocyte.

Author information

1
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. agnes.fogo@vanderbilt.edu

Abstract

The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte.

PMID:
21606599
PMCID:
PMC3104780
DOI:
10.1172/JCI57935
[Indexed for MEDLINE]
Free PMC Article

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